Description

1-(2,4,6-Trifluorobenzyl)Piperidin-4-Amine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its dihydrochloride salt form, which enhances stability and handling properties. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and other therapeutic areas. It is primarily required by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and biotechnology industries engaged in drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to develop new chemical entities with improved efficacy and safety profiles.
• Process Development & Scale-up: Serves as a standard material for developing robust, scalable, and cost-effective synthetic routes from laboratory to pilot plant and commercial production.
• Reference Standard: Employed as an analytical standard for method development, validation, and quality control of final APIs in compliance with regulatory guidelines.
• Bioconjugation & Probe Synthesis: The amine functionality allows for its use in creating labeled compounds or molecular probes for biochemical and pharmacological assays.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	1-(2,4,6-Trifluorobenzyl)Piperidin-4-Amine Dihydrochloride
CAS No.	1286275-19-1
Molecular Formula	C12H15F3N2 • 2HCl
Molecular Weight	309.17 g/mol (Free base)
Synonyms	4-Amino-1-[(2,4,6-trifluorophenyl)methyl]piperidine Dihydrochloride; 1-[(2,4,6-Trifluorophenyl)methyl]-4-piperidinamine Dihydrochloride; 1-(2,4,6-Trifluorobenzyl)-4-aminopiperidine Dihydrochloride; 4-Amino-1-(2,4,6-trifluorobenzyl)piperidine Dihydrochloride; 1-(2,4,6-Trifluorobenzyl)piperidin-4-ylamine Dihydrochloride; Piperidin-4-amine, 1-[(2,4,6-trifluorophenyl)methyl]-, dihydrochloride
EINECS	Contact for details

Quality Control

Our 1-(2,4,6-Trifluorobenzyl)Piperidin-4-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and development. Certificates of Analysis (COA) detailing HPLC purity, NMR confirmation, and residual solvent analysis are provided with every shipment. We support development projects with material produced under quality agreements and can supply material suitable for use under cGMP guidelines for Phase-appropriate clinical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to prevent degradation upon exposure to air. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.