Description

tert-Butyl 1-(2,5-Difluorobenzyl)Piperidin-4-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core with a difluorobenzyl substituent and a Boc-protected amine. This compound is critical for medicinal chemistry research and development, offering a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents, particularly in areas such as central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, particularly those targeting protease or kinase enzymes.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the pharmacokinetic and pharmacodynamic properties of lead compounds.
• API Synthesis: Serves as a precursor in the final stages of synthesizing complex Active Pharmaceutical Ingredients (APIs) for preclinical and clinical trials.
• Chemical Library Development: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) in drug discovery programs.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke molecules for client projects.
• Process Chemistry Development: Used to develop and scale up efficient, cost-effective synthetic routes for potential commercial drug manufacturing.

Basic Information

Product Name	tert-Butyl 1-(2,5-Difluorobenzyl)Piperidin-4-Ylcarbamate
CAS No.	1286274-90-5
Molecular Formula	C18H26F2N2O2
Molecular Weight	340.41 g/mol
Synonyms	1-(2,5-Difluorobenzyl)-N-(tert-butoxycarbonyl)piperidin-4-amine; tert-Butyl N-[1-[(2,5-difluorophenyl)methyl]piperidin-4-yl]carbamate; 4-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-[(2,5-difluorophenyl)methyl]piperidine; 1-(2,5-Difluorobenzyl)piperidin-4-amine, N-Boc-protected; Boc-4-amino-1-(2,5-difluorobenzyl)piperidine; 1286274-90-5; tert-Butyl (1-(2,5-difluorobenzyl)piperidin-4-yl)carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-(2,5-Difluorobenzyl)Piperidin-4-Ylcarbamate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.