Description

1-(5-Chloro-2-Fluorobenzyl)Piperidin-4-Amine Dihydrochloride is a high-purity, pharmaceutically relevant chemical intermediate with the CAS number 1286274-03-0. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by pharmaceutical R&D laboratories, contract research/manufacturing organizations (CROs/CMOs), and fine chemical producers engaged in advanced medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a starting material or intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Biochemical Research: Employed in the development of receptor ligands and enzyme inhibitors for pharmacological studies.
• Custom Synthesis: A foundational component for the contract manufacturing of complex, high-value specialty chemicals.

Basic Information

Product Name	1-(5-Chloro-2-Fluorobenzyl)Piperidin-4-Amine Dihydrochloride
CAS No.	1286274-03-0
Molecular Formula	C12H17Cl2FN2
Molecular Weight	279.18 g/mol
Synonyms	4-Amino-1-[(5-chloro-2-fluorophenyl)methyl]piperidine dihydrochloride; 1-[(5-Chloro-2-fluorophenyl)methyl]-4-piperidinamine dihydrochloride; 1-(5-Chloro-2-fluorobenzyl)piperidin-4-amine hydrochloride (1:2); 4-Amino-1-(5-chloro-2-fluorobenzyl)piperidine dihydrochloride; 1-(5-Chloro-2-fluorobenzyl)-4-piperidinamine dihydrochloride
EINECS	Contact for details

Quality Control

Our 1-(5-Chloro-2-Fluorobenzyl)Piperidin-4-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.