Description

3-[(4-Aminopiperidin-1-Yl)Methyl]Benzonitrile Dihydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its benzonitrile and aminopiperidine functional groups. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block in the synthesis of novel drug candidates. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in the discovery of new therapeutic agents, particularly in areas targeting central nervous system (CNS) disorders and other receptor-mediated pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Development: The aminopiperidine moiety makes it relevant for research into inhibitors of various enzymatic targets.
• Ligand Synthesis for Receptor Studies: Employed in creating novel ligands for pharmacological characterization of G-protein coupled receptors (GPCRs) and other targets.
• Chemical Biology Probes: Useful for developing tool compounds to study biological pathways and validate new drug targets.
• Custom Synthesis Building Block: Supplied to fine chemical manufacturers for bespoke synthesis projects under cGMP or research-grade conditions.

Basic Information

Item	Detail
Product Name	3-[(4-Aminopiperidin-1-Yl)Methyl]Benzonitrile Dihydrochloride
CAS No.	1286273-82-2
Molecular Formula	C13H18N4 · 2HCl
Molecular Weight	303.23 g/mol (Free base: 230.31 g/mol)
Synonyms	1-[(3-Cyanophenyl)methyl]-4-piperidinamine dihydrochloride; 3-((4-Aminopiperidin-1-yl)methyl)benzonitrile dihydrochloride; 4-Amino-1-[(3-cyanophenyl)methyl]piperidinium chloride hydrochloride; 3-(4-Aminopiperidin-1-ylmethyl)benzonitrile dihydrochloride; 3-[(4-Amino-1-piperidinyl)methyl]benzonitrile dihydrochloride; 1286273-82-2; 3-Cyanobenzyl-4-aminopiperidine dihydrochloride
EINECS	Contact for details

Quality Control

Our 3-[(4-Aminopiperidin-1-Yl)Methyl]Benzonitrile Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) documenting identity, purity, and safety parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under anhydrous conditions to prevent degradation. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.