Description

1-(3-Chloro-4-Fluorobenzyl)Piperidin-4-Amine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated benzyl-piperidine amine structure. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of potential drug candidates, particularly those targeting receptor-based pathways.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its modifiable amine and halogenated aromatic groups.
• Process Chemistry & Scale-Up: Serves as a defined starting material or intermediate in the development and optimization of GMP-compliant synthetic routes for API manufacturing.
• Biochemical Tool Compound: May be utilized in the development of assay probes or labeled ligands for pharmacological and diagnostic research.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development programs for global clients.

Basic Information

Item	Details
Product Name	1-(3-Chloro-4-Fluorobenzyl)Piperidin-4-Amine Dihydrochloride
CAS No.	1286266-07-6
Molecular Formula	C12H17ClF N2 • 2HCl
Molecular Weight	313.65 g/mol (Free base: 240.73 g/mol)
Synonyms	4-Amino-1-[(3-chloro-4-fluorophenyl)methyl]piperidine dihydrochloride; 1-[(3-Chloro-4-fluorophenyl)methyl]-4-piperidinamine dihydrochloride; (3-Chloro-4-fluorobenzyl)piperidin-4-amine dihydrochloride; 4-Amino-1-(3-chloro-4-fluorobenzyl)piperidine dihydrochloride; Piperidin-4-amine, 1-[(3-chloro-4-fluorophenyl)methyl]-, dihydrochloride; 1-(3-Chloro-4-fluorobenzyl)-4-aminopiperidine dihydrochloride
EINECS	Contact for details

Quality Control

Every batch of 1-(3-Chloro-4-Fluorobenzyl)Piperidin-4-Amine Dihydrochloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to support its use in regulated research environments. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot and provided upon request. Our standard quality commitment ensures the material meets the stringent requirements for pharmaceutical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.