Description

[4-(Aminomethyl)Piperidin-1-Yl](Pyridin-4-Yl)Methanone Dihydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a piperidine-pyridine core structure. This compound is critical for medicinal chemistry research and development, serving as a key building block for synthesizing novel bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry.
• Protease Inhibitor Research: Used in the development of inhibitors targeting specific enzymes for therapeutic applications.
• Kinase Inhibitor Synthesis: Serves as a core scaffold or precursor in the creation of kinase inhibitors for oncology research.
• Chemical Biology & Probe Development: Employed in the design and synthesis of chemical probes to study biological pathways and protein function.
• Peptidomimetic Chemistry: Acts as a constrained scaffold to mimic peptide structures, enhancing metabolic stability and bioavailability in drug design.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) laboratories for exploratory synthesis and hit-to-lead optimization.

Basic Information

Product Name	[4-(Aminomethyl)Piperidin-1-Yl](Pyridin-4-Yl)Methanone Dihydrochloride
CAS No.	1286265-79-9
Molecular Formula	C12H17N3O • 2HCl
Molecular Weight	292.21 g/mol (Free base: 219.29 g/mol)
Synonyms	4-(Aminomethyl)-1-(pyridine-4-carbonyl)piperidine dihydrochloride; 1-(4-Pyridinylcarbonyl)-4-(aminomethyl)piperidine dihydrochloride; (4-(Aminomethyl)piperidin-1-yl)(pyridin-4-yl)methanone hydrochloride (1:2); 4-(Aminomethyl)-N-(4-pyridinyl)-1-piperidinecarboxamide dihydrochloride; 1286265-79-9; UNII-6V5I4V7W9R; 6V5I4V7W9R; SCHEMBL23306211
EINECS	Contact for details

Quality Control

Our [4-(Aminomethyl)Piperidin-1-Yl](Pyridin-4-Yl)Methanone Dihydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.