Description

(R)-tert-Butyl 3-(3-Nitropyridin-2-Yloxy)Pyrrolidine-1-Carboxylate is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex, biologically active molecules, particularly in the development of new therapeutic agents. It is primarily required by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially for central nervous system (CNS) and antiviral targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its defined stereochemistry and functional groups.
• Process Chemistry: Serves as a critical starting material or intermediate in the scale-up and commercial synthesis of complex APIs under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Employed as a building block for constructing more complex chiral molecules, leveraging its pyrrolidine and nitropyridine moieties.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical industry.

Basic Information

Product Name	(R)-tert-Butyl 3-(3-Nitropyridin-2-Yloxy)Pyrrolidine-1-Carboxylate
CAS No.	1286208-30-7
Molecular Formula	C14H19N3O5
Molecular Weight	309.32 g/mol
Synonyms	1-Boc-3-((3-nitropyridin-2-yl)oxy)-(R)-pyrrolidine; (R)-1-(tert-Butoxycarbonyl)-3-[(3-nitropyridin-2-yl)oxy]pyrrolidine; tert-Butyl (3R)-3-[(3-nitropyridin-2-yl)oxy]pyrrolidine-1-carboxylate; (R)-tert-Butyl 3-((3-nitropyridin-2-yl)oxy)pyrrolidine-1-carboxylate; (R)-1-Boc-3-(3-nitropyridin-2-yloxy)pyrrolidine; (R)-N-Boc-3-(3-nitropyridin-2-yloxy)pyrrolidine; (R)-3-(3-Nitropyridin-2-yloxy)pyrrolidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 3-(3-Nitropyridin-2-Yloxy)Pyrrolidine-1-Carboxylate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral purity and chemical purity assays, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.