Description

(S)-tert-Butyl 1-Isobutylpyrrolidin-3-Ylcarbamate is a high-purity chiral intermediate featuring a protected amine group on a pyrrolidine scaffold. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecules with specific stereochemistry.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of potential therapeutic agents, including protease inhibitors and neurological drugs.
• Asymmetric Synthesis: Utilized in the construction of complex, stereochemically defined molecules for medicinal chemistry and catalyst development.
• Peptidomimetic Research: Serves as a proline-like scaffold for developing peptide mimics with enhanced metabolic stability and bioavailability.
• Chemical Biology Probes: Used to create labeled or modified compounds for studying biological pathways and target engagement.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for advanced pharmaceutical intermediates.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	(S)-tert-Butyl 1-Isobutylpyrrolidin-3-Ylcarbamate
CAS No.	1286207-83-7
Molecular Formula	C13H26N2O2
Molecular Weight	242.36 g/mol
Synonyms	1-Isobutyl-3-[[(1,1-dimethylethoxy)carbonyl]amino]-(3S)-pyrrolidine; (3S)-1-(2-Methylpropyl)-N-(tert-butoxycarbonyl)pyrrolidin-3-amine; tert-Butyl N-[(3S)-1-(2-methylpropyl)pyrrolidin-3-yl]carbamate; (S)-1-Isobutyl-3-(Boc-amino)pyrrolidine; (S)-tert-Butyl (1-isobutylpyrrolidin-3-yl)carbamate; Boc-(S)-1-Isobutyl-3-aminopyrrolidine; (S)-Boc-1-Isobutyl-3-aminopyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 1-Isobutylpyrrolidin-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (HPLC), and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.