Description

(R)-tert-Butyl 3-(5-Aminopyridin-2-Yloxy)Pyrrolidine-1-Carboxylate is a high-purity chiral building block and Boc-protected pyrrolidine derivative of significant value in advanced organic synthesis. This compound matters as a critical intermediate for constructing complex molecules with defined stereochemistry, enabling the development of targeted pharmaceuticals. It is primarily needed by research and development teams in the pharmaceutical and biotechnology sectors, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and antiviral therapies.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) requiring a specific (R)-configured pyrrolidine scaffold.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing focused libraries of compounds in structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to introduce chirality into target molecules.
• Peptidomimetics Development: Useful for creating pyrrolidine-based scaffolds that mimic peptide structures in drug design.
• Chemical Biology Probes: Can be utilized to synthesize molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	(R)-tert-Butyl 3-(5-Aminopyridin-2-Yloxy)Pyrrolidine-1-Carboxylate
CAS No.	1286207-78-0
Molecular Formula	C14H21N3O3
Molecular Weight	279.34 g/mol
Synonyms	1-Boc-3-((5-amino-2-pyridyl)oxy)-(R)-pyrrolidine; (R)-1-(tert-Butoxycarbonyl)-3-[(5-amino-2-pyridinyl)oxy]pyrrolidine; tert-Butyl (3R)-3-[(5-aminopyridin-2-yl)oxy]pyrrolidine-1-carboxylate; (R)-tert-Butyl 3-((5-aminopyridin-2-yl)oxy)pyrrolidine-1-carboxylate; (R)-N-Boc-3-(5-amino-2-pyridyloxy)pyrrolidine; (R)-1-Boc-3-(5-aminopyridin-2-yloxy)pyrrolidine; (R)-3-(5-Amino-pyridin-2-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 3-(5-Aminopyridin-2-Yloxy)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.