Description

(S)-3-Nitro-2-(Pyrrolidin-3-Yloxy)Pyridine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of targeted small molecule therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of novel drug candidates.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore novel chemical space.
• Asymmetric Synthesis: Serves as a valuable precursor for constructing complex molecules with defined stereochemistry due to its (S)-configured pyrrolidine moiety.
• Chemical Biology Probes: Employed in the development of tool compounds and molecular probes for studying biological pathways and target validation.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant scale for clinical trial material production.
• Academic Research: Utilized in university and institutional labs for advanced organic synthesis and methodology development projects.

Basic Information

Product Name	(S)-3-Nitro-2-(Pyrrolidin-3-Yloxy)Pyridine Hydrochloride
CAS No.	1286207-32-6
Molecular Formula	C9H12N3O3·HCl
Molecular Weight	261.67 g/mol
Synonyms	(S)-3-Nitro-2-((3-pyrrolidinyl)oxy)pyridine hydrochloride; (S)-2-((Pyrrolidin-3-yl)oxy)-3-nitropyridine hydrochloride; (S)-3-NO2-2-(3-Pyrrolidinyloxy)Pyridine HCl; Pyridine, 3-nitro-2-[(3S)-3-pyrrolidinyl]oxy-, hydrochloride (1:1); (S)-enantiomer of 3-Nitro-2-(pyrrolidin-3-yloxy)pyridine HCl
EINECS	Contact for details

Quality Control

Our (S)-3-Nitro-2-(Pyrrolidin-3-Yloxy)Pyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.