Description

(R)-tert-Butyl 1-Isobutylpyrrolidin-3-Ylcarbamate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound is valued for its role as a key building block in the development of active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is primarily needed by research institutions, custom synthesis laboratories, and pharmaceutical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used in the preparation of enantiomerically pure compounds for medicinal chemistry research and development.
• Neurological Drug Research: Serves as a precursor in the development of potential therapeutics for neurological and psychiatric disorders.
• Process Chemistry: Employed in route scouting and scale-up processes for new chemical entities (NCEs) in pilot plants and commercial manufacturing.
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule assembly.
• Chemical Reference Standard: Acts as a high-purity standard for analytical method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	(R)-tert-Butyl 1-Isobutylpyrrolidin-3-Ylcarbamate
CAS No.	1286207-16-6
Molecular Formula	C13H26N2O2
Molecular Weight	242.36 g/mol
Synonyms	1-Isobutyl-3-[(tert-butoxycarbonyl)amino]pyrrolidine, (R)-; (R)-1-Isobutyl-3-((tert-butoxycarbonyl)amino)pyrrolidine; tert-Butyl N-[(3R)-1-(2-methylpropyl)pyrrolidin-3-yl]carbamate; (R)-tert-Butyl (1-isobutylpyrrolidin-3-yl)carbamate; Boc-(R)-1-Isobutyl-3-aminopyrrolidine; (R)-1-Isobutyl-3-(Boc-amino)pyrrolidine; Carbamic acid, N-[(3R)-1-(2-methylpropyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 1-Isobutylpyrrolidin-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.