Description

2-Piperazinone, 1-(Tetrahydro-2H-Pyran-4-Yl)-, Hydrochloride (1:1) is a high-purity, advanced pharmaceutical intermediate with a defined molecular structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, where consistent quality and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug molecules, especially those targeting the central nervous system (CNS) and other therapeutic areas.
• Organic Synthesis Reagent: Used in academic and industrial laboratories for constructing complex piperazinone and tetrahydropyran-containing heterocycles.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Pre-clinical Development: Employed in the production of compounds for pharmacological evaluation, toxicology studies, and formulation development.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-compliant production of clinical trial materials.

Basic Information

Product Name	2-Piperazinone, 1-(Tetrahydro-2H-Pyran-4-Yl)-, Hydrochloride (1:1)
CAS No.	1284244-13-8
Molecular Formula	C9H17ClN2O2
Molecular Weight	220.70 g/mol
Synonyms	1-(Oxan-4-yl)piperazin-2-one hydrochloride; 1-(Tetrahydro-2H-pyran-4-yl)piperazin-2-one hydrochloride; 1-(Tetrahydropyran-4-yl)-2-piperazinone hydrochloride; 2-Piperazinone, 1-(tetrahydro-2H-pyran-4-yl)-, hydrochloride; 1284244-13-8; 1-(Oxan-4-yl)piperazin-2-one HCl; 1-(Tetrahydro-2H-pyran-4-yl)-2-piperazinone HCl
EINECS	Contact for details

Quality Control

Our 2-Piperazinone, 1-(Tetrahydro-2H-Pyran-4-Yl)-, Hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Assay (Titration)	98.0 - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.