Description

tert-Butyl 4-(4-Fluorophenyl)-3-oxopiperazine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its piperazine-dione core structure. This compound is of significant commercial importance as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and scale-up of novel therapeutic agents, where reliable quality and consistent supply are critical.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of potent drug candidates, especially in neurological and psychiatric research.
• API Synthesis: Serves as a key scaffold for constructing complex molecules with potential activity as kinase inhibitors or receptor modulators.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities.
• Process Chemistry & Scale-Up: Employed in route development and pilot-scale manufacturing for clinical trial material supply.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control.

Basic Information

Product Name	tert-Butyl 4-(4-Fluorophenyl)-3-oxopiperazine-1-carboxylate
CAS No.	1284243-44-2
Molecular Formula	C15H19FN2O3
Molecular Weight	294.32 g/mol
Synonyms	1-Boc-4-(4-fluorophenyl)-3-oxopiperazine; 1-(tert-Butoxycarbonyl)-4-(4-fluorophenyl)-2,3-dioxopiperazine; tert-Butyl 4-(4-fluorophenyl)-2,3-dioxo-1-piperazinecarboxylate; 4-(4-Fluorophenyl)-3-oxopiperazine-1-carboxylic acid tert-butyl ester; 3-Oxo-4-(4-fluorophenyl)piperazine-1-carboxylic acid tert-butyl ester; 1284243-44-2; BOC-4-(4-Fluorophenyl)-3-oxopiperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4-Fluorophenyl)-3-oxopiperazine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.