Description

tert-Butyl 4-Hydroxy-3-(Trifluoromethyl)Piperidine-1-Carboxylate is a high-value, protected piperidine derivative that serves as a critical synthetic intermediate in advanced organic chemistry. This compound is particularly significant for its trifluoromethyl and hydroxyl functional groups, which are key motifs for modulating the physicochemical and metabolic properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Chemical Biology & Proteomics: Employed as a scaffold or linker in the design of chemical probes and activity-based protein profiling (ABPP) reagents.
• Material Science Research: Serves as a monomer or functional additive in the development of specialty polymers with unique surface properties.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	tert-Butyl 4-Hydroxy-3-(Trifluoromethyl)Piperidine-1-Carboxylate
CAS No.	1283720-71-7
Molecular Formula	C11H18F3NO3
Molecular Weight	269.26 g/mol
Synonyms	1-Boc-4-hydroxy-3-(trifluoromethyl)piperidine; 4-Hydroxy-3-(trifluoromethyl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-hydroxy-3-(trifluoromethyl)-1-piperidinecarboxylate; 3-(Trifluoromethyl)-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester; 1-N-Boc-4-hydroxy-3-trifluoromethylpiperidine; N-Boc-4-hydroxy-3-(trifluoromethyl)piperidine; Boc-4-hydroxy-3-CF3-piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Hydroxy-3-(Trifluoromethyl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.