Description

(3R)-3-(Trifluoromethyl)Piperidine CAS NO 1282530-77-1 is a high-value, chiral piperidine derivative distinguished by its trifluoromethyl group, a key structural motif that imparts unique physicochemical properties. This compound is critical for pharmaceutical and agrochemical research, where it serves as a versatile building block for creating molecules with enhanced metabolic stability, lipophilicity, and bioavailability. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for the synthesis of novel active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of central nervous system (CNS) drugs, enzyme inhibitors, and receptor modulators.
• Agrochemical Synthesis: Used as a building block for novel herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group to improve efficacy and environmental profile.
• Ligand and Catalyst Development: Employed in the design of chiral ligands and organocatalysts for asymmetric synthesis.
• Material Science Research: Investigated as a component for advanced polymers and liquid crystals due to its fluorine-containing moiety.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological pathways and protein function.
• Process Chemistry & Scale-up: Serves as a critical intermediate in the optimization and commercial-scale production of fine chemicals.

Basic Information

Product Name	(3R)-3-(Trifluoromethyl)Piperidine
CAS No.	1282530-77-1
Molecular Formula	C6H10F3N
Molecular Weight	153.15 g/mol
Synonyms	(R)-3-(Trifluoromethyl)piperidine; (3R)-3-(Trifluoromethyl)piperidine; (R)-3-Trifluoromethylpiperidine; 3-(Trifluoromethyl)piperidine, (3R)-; (+)-3-(Trifluoromethyl)piperidine; (R)-(+)-3-(Trifluoromethyl)piperidine; 1,2,3,4-Tetrahydro-3-(trifluoromethyl)pyridine, (3R)-; Piperidine, 3-(trifluoromethyl)-, (3R)-
EINECS	Contact for details

Quality Control

Our (3R)-3-(Trifluoromethyl)Piperidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) and spectroscopic confirmation (NMR, IR) are provided to guarantee traceability, consistency, and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain purity and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.