Description

1-(5-Bromopyridin-3-Ylsulfonyl)-4-Methylpyrrolidin-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its bromopyridine and sulfonyl pyrrolidinone structure. This compound is of significant value for medicinal chemistry research and development, serving as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, particularly kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new therapeutic molecules.
• Biochemical Tool Compound: May serve as a research probe or a ligand in biochemical assays to study specific biological pathways.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing specialized, high-value chemical entities.
• Agrochemical Research: Potential application as an intermediate in the development of new crop protection agents.

Basic Information

Product Name	1-(5-Bromopyridin-3-Ylsulfonyl)-4-Methylpyrrolidin-2-One
CAS No.	1275420-54-6
Molecular Formula	C10H11BrN2O3S
Molecular Weight	319.18 g/mol
Synonyms	4-Methyl-1-[(5-bromopyridin-3-yl)sulfonyl]pyrrolidin-2-one; 1-[(5-Bromo-3-pyridinyl)sulfonyl]-4-methyl-2-pyrrolidinone; 4-Methyl-1-(5-bromopyridine-3-sulfonyl)pyrrolidin-2-one; 1275420-54-6; 1-(5-Bromopyridine-3-sulfonyl)-4-methylpyrrolidin-2-one
EINECS	Contact for details

Quality Control

Our 1-(5-Bromopyridin-3-Ylsulfonyl)-4-Methylpyrrolidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.