Description

(7S,8As)-tert-Butyl 7-Hydroxyhexahydropyrrolo[1,2-A]Pyrazine-2(1H)-Carboxylate CAS NO 1273564-60-5 is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound matters as a critical building block in the synthesis of complex, biologically active molecules, offering precise structural control for research and development. It is primarily needed by pharmaceutical companies, biotechnology firms, and contract research organizations (CROs) engaged in the development of new therapeutic agents, particularly in areas requiring sophisticated chiral chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or anti-infective drug candidates.
• Peptidomimetic Chemistry: Serves as a constrained scaffold for designing and synthesizing peptidomimetics, which are crucial in developing more stable and bioavailable drug-like molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities with potential therapeutic value.
• Asymmetric Synthesis: Employed as a starting material or intermediate in asymmetric catalytic processes to introduce chirality into target molecules.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and chemical biology.

Basic Information

Product Name	(7S,8As)-tert-Butyl 7-Hydroxyhexahydropyrrolo[1,2-A]Pyrazine-2(1H)-Carboxylate
CAS No.	1273564-60-5
Molecular Formula	C12H22N2O3
Molecular Weight	242.32 g/mol
Synonyms	tert-Butyl (7S,8aS)-7-hydroxyhexahydro-1H-pyrrolo[1,2-a]pyrazine-2(6H)-carboxylate; (7S,8aS)-2-(tert-Butoxycarbonyl)-7-hydroxyoctahydropyrrolo[1,2-a]pyrazine; BOC-Hydroxy Hexahydropyrrolopyrazine; (7S,8aS)-Boc-7-hydroxyhexahydropyrrolo[1,2-a]pyrazine; Chiral Pyrrolopyrazine Derivative; BOC-Protected Hydroxy Pyrrolopyrazine; (7S,8aS)-tert-Butyl 7-hydroxyoctahydro-1H-pyrrolo[1,2-a]pyrazine-2-carboxylate
EINECS	Contact for details

Quality Control

Our (7S,8As)-tert-Butyl 7-Hydroxyhexahydropyrrolo[1,2-A]Pyrazine-2(1H)-Carboxylate is manufactured under strict quality management systems. Products undergo rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for advanced pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. We support development and commercial projects with specifications aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light) and should be handled in environments compatible with strong acid/organic solvent. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.