Description

5-Trifluoromethyl-Piperidine-3-Carboxylic Acid Methyl Ester is a high-value fluorinated piperidine derivative, a crucial chiral building block in modern synthetic chemistry. Its core value lies in the strategic incorporation of a trifluoromethyl group, which significantly alters the physicochemical properties of target molecules, enhancing their metabolic stability and lipophilicity. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry for central nervous system (CNS) and other therapeutic targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, especially in areas targeting neurological disorders, psychiatric conditions, and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Advanced Material Precursor: Serves as a building block for specialty chemicals and functional materials requiring specific fluorine-containing motifs.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis to explore new chemical spaces in drug discovery programs.
• Process Chemistry & Scale-up: Used in route scouting and optimization for the commercial-scale production of complex molecules containing the trifluoromethyl-piperidine moiety.

Basic Information

Product Name	5-Trifluoromethyl-Piperidine-3-Carboxylic Acid Methyl Ester
CAS No.	1269755-53-4
Molecular Formula	C8H12F3NO2
Molecular Weight	211.18 g/mol
Synonyms	Methyl 5-(trifluoromethyl)piperidine-3-carboxylate; 3-Piperidinecarboxylic acid, 5-(trifluoromethyl)-, methyl ester; Methyl 5-trifluoromethylnipecotate; 5-(Trifluoromethyl)nipecotic acid methyl ester
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our advanced intermediates. Production follows current Good Manufacturing Practice (cGMP) principles where applicable, and each batch is analyzed to ensure high chemical and chiral purity. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing specifications for identity, assay, impurity profile (by HPLC/GC), and other critical parameters. Our quality system is designed to meet the exacting standards of pharmaceutical and agrochemical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomer specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.