Description

Rel-tert-Butyl (2R,5R)-2,5-Dimethylpiperazine-1-Carboxylate Hydrochloride is a high-purity chiral piperazine derivative, a crucial building block in advanced pharmaceutical synthesis. Its defined stereochemistry and protected amine functionality make it an essential intermediate for developing active pharmaceutical ingredients (APIs) with precise molecular configurations. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in areas requiring sophisticated chiral amine chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, particularly for central nervous system (CNS) and antiviral agents.
• Asymmetric Catalyst Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in asymmetric hydrogenation and other enantioselective transformations.
• Protease Inhibitor Research: Used in the development of protease inhibitors, where the piperazine scaffold is a common structural motif.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and library synthesis for high-throughput screening.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis under cGMP conditions.
• Academic & Industrial R&D: Used in research laboratories for methodological development in organic synthesis and novel heterocycle construction.

Basic Information

Product Name	Rel-tert-Butyl (2R,5R)-2,5-Dimethylpiperazine-1-Carboxylate Hydrochloride
CAS No.	1269483-76-2
Molecular Formula	C11H23ClN2O2
Molecular Weight	250.77 g/mol
Synonyms	1-Boc-2,5-dimethylpiperazine hydrochloride (rel-(2R,5R)-isomer); tert-Butyl (2R,5R)-2,5-dimethylpiperazine-1-carboxylate hydrochloride; (2R,5R)-1-(tert-Butoxycarbonyl)-2,5-dimethylpiperazine hydrochloride; N-Boc-2,5-dimethylpiperazine HCl (rel-(2R,5R)-form); rel-(2R,5R)-2,5-Dimethyl-1-(tert-butoxycarbonyl)piperazine hydrochloride; Boc-2,5-dimethylpiperazine hydrochloride (racemic of (2R,5R) enantiomer); Piperazine, 2,5-dimethyl-1-[(1,1-dimethylethoxy)carbonyl]-, hydrochloride, (2R,5R)-rel-
EINECS	Contact for details

Quality Control

Our Rel-tert-Butyl (2R,5R)-2,5-Dimethylpiperazine-1-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, chiral assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.