Description

tert-Butyl 2-(Dimethylcarbamoyl)Piperazine-1-Carboxylate Hydrochloride is a high-purity, protected piperazine derivative and a key pharmaceutical intermediate. Its value lies in providing a versatile and reactive scaffold for the synthesis of complex molecules, particularly in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology industries developing new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• API Synthesis: Used in constructing the core piperazine moiety for potential APIs, leveraging its protected amine and carbamate functionalities.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Peptidomimetic Development: Employed in the design and synthesis of peptide analogs and mimetics due to its piperazine structure.
• Chemical Biology Probes: Acts as a starting material for creating specialized probes and ligands used in biochemical assays.
• Custom Synthesis: A foundational reagent for contract research and manufacturing organizations (CROs/CMOs) producing bespoke fine chemicals.

Basic Information

Product Name	tert-Butyl 2-(Dimethylcarbamoyl)Piperazine-1-Carboxylate Hydrochloride
CAS No.	1269446-23-2
Molecular Formula	C12H24ClN3O3
Molecular Weight	293.79 g/mol
Synonyms	1-Boc-2-(N,N-dimethylcarbamoyl)piperazine hydrochloride; tert-Butyl 2-(dimethylaminocarbonyl)piperazine-1-carboxylate hydrochloride; 1-(tert-Butoxycarbonyl)-2-(dimethylcarbamoyl)piperazine hydrochloride; 2-(Dimethylcarbamoyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester hydrochloride; Piperazine-1-carboxylic acid, 2-(dimethylaminocarbonyl)-, 1,1-dimethylethyl ester, hydrochloride; 1-Boc-2-(dimethylcarbamoyl)piperazine HCl; BOC-2-(N,N-Dimethylcarbamoyl)piperazine HCl
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(Dimethylcarbamoyl)Piperazine-1-Carboxylate Hydrochloride is manufactured under strict quality systems suitable for research and pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), residual solvents, and other critical parameters is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere or with desiccant for long-term preservation to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.