Description

2,5-Diazabicyclo[2.2.1]heptane-2-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride (1:1), (1R,4R)- is a high-purity, chiral bicyclic diamino acid derivative. This compound is a critical pharmaceutical intermediate and building block for advanced organic synthesis, valued for its rigid, three-dimensional structure. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the development of novel active pharmaceutical ingredients (APIs), particularly in areas like protease inhibitors and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Development: Used in research and production of inhibitors targeting specific enzymes like HCV NS3/4A protease.
• Asymmetric Synthesis: Serves as a precursor for chiral catalysts or ligands due to its defined (1R,4R) stereochemistry.
• Peptidomimetics: Incorporated into peptide analogs to enhance metabolic stability and bioavailability.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and library synthesis for drug discovery.
• Process Chemistry: Used in scale-up and optimization of synthetic routes for commercial pharmaceutical manufacturing.

Basic Information

Product Name	2,5-Diazabicyclo[2.2.1]heptane-2-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride (1:1), (1R,4R)-
CAS No.	1269437-74-2
Molecular Formula	C11H21N2O2 • HCl
Molecular Weight	264.76 g/mol (as hydrochloride salt)
Synonyms	(1R,4R)-2-(tert-Butoxycarbonyl)-2,5-diazabicyclo[2.2.1]heptane hydrochloride; (1R,4R)-N-Boc-2,5-diazabicyclo[2.2.1]heptane hydrochloride; (1R,4R)-tert-Butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate hydrochloride; (1R,4R)-Boc-DABCO-Heptane HCl; (1R,4R)-Boc-2,5-diazabicyclo[2.2.1]heptane HCl; (1R,4R)-2,5-Diazabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester hydrochloride; (1R,4R)-endo-N-Boc-2,5-diazabicyclo[2.2.1]heptane hydrochloride
EINECS	Contact for details

Quality Control

Our 2,5-Diazabicyclo[2.2.1]heptane-2-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride (1:1), (1R,4R)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D. Production adheres to cGMP guidelines where applicable. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.