Description

trans-1-Cbz-4-Amino-3-Fluoropiperidine is a high-purity, fluorinated piperidine derivative, serving as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring a protected amine and a fluorine atom on the piperidine ring, makes it an invaluable intermediate for constructing complex molecules with enhanced biological activity and metabolic stability. This compound is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams focused on developing new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel drug candidates, including kinase inhibitors and central nervous system (CNS) agents.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to explore the impact of fluorination and amine protection on potency and pharmacokinetics.
• Peptidomimetics: Serves as a constrained, fluorinated amino acid surrogate in the design of peptide analogs with improved stability and bioavailability.
• Agrochemical Research: Intermediate in the synthesis of advanced, fluorinated active ingredients for crop protection products.
• Chemical Biology Probes: Building block for creating labeled compounds and probes used to study biological pathways and enzyme functions.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke, multi-step synthetic routes for clients.

Basic Information

Item	Detail
Product Name	trans-1-Cbz-4-Amino-3-Fluoropiperidine
CAS No.	1268520-05-3
Molecular Formula	C13H17FN2O2
Molecular Weight	252.29 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-4-amino-3-fluoropiperidine, trans-; (3R,4S)-1-[(Benzyloxy)carbonyl]-4-amino-3-fluoropiperidine; (3S,4R)-1-[(Benzyloxy)carbonyl]-4-amino-3-fluoropiperidine; 3-Fluoro-4-aminopiperidine-1-carboxylic acid benzyl ester; 4-Amino-3-fluoro-1-N-CBZ-piperidine; trans-4-Amino-3-fluoro-1-Cbz-piperidine; 1-Cbz-4-amino-3-fluoropiperidine; Benzyl 4-amino-3-fluoropiperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our trans-1-Cbz-4-Amino-3-Fluoropiperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting your regulatory and quality assurance documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.