Description

Bis-Peg10-Acid CAS NO 1268488-70-5 is a high-purity, bifunctional polyethylene glycol (PEG) derivative featuring two terminal carboxylic acid groups. This structure is critical for its role as a versatile hydrophilic linker and spacer molecule in advanced bioconjugation and polymer chemistry. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise, water-soluble crosslinking agents to develop drug delivery systems, hydrogels, and functionalized surfaces.

Application

• Pharmaceutical Linker: A key intermediate for conjugating active pharmaceutical ingredients (APIs) to antibodies, peptides, or nanoparticles in ADC (Antibody-Drug Conjugate) and prodrug development.
• PEGylation Reagent: Used to modify proteins, peptides, and oligonucleotides to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Polymer Synthesis: Serves as a difunctional monomer for creating biodegradable, hydrophilic block copolymers and dendrimers for controlled release applications.
• Hydrogel Formation: Acts as a crosslinking agent in the synthesis of biocompatible hydrogels for tissue engineering, wound dressings, and contact lenses.
• Surface Functionalization: Used to create PEGylated surfaces on medical devices and diagnostic chips to impart antifouling properties and enable further bioconjugation.
• Diagnostic Reagents: Employed in the development of fluorescent probes, contrast agents, and assay components where water solubility and specific conjugation are required.

Basic Information

Product Name	Bis-Peg10-Acid
CAS No.	1268488-70-5
Molecular Formula	C24H46O23
Molecular Weight	654.6 g/mol
Synonyms	α,ω-Bis(carboxy)poly(oxy-1,2-ethanediyl); PEG-10 Dicarboxylic Acid; Bis(carboxymethyl) PEG-10; 3,6,9,12,15,18,21,24,27,30-Decaoxadotetracontanedioic Acid; Polyethylene glycol 500 dicarboxylic acid; Bis-PEG10-diacid; HOOC-PEG10-COOH; Dicarboxy-terminated PEG-10
EINECS	Contact for details

Quality Control

Our Bis-Peg10-Acid is manufactured under GMP-like conditions to ensure batch-to-batch consistency and high purity for sensitive applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and Karl Fischer titration for water content. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and prevent hydrolysis of the terminal acid groups.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Acid Value	Contact for details
Polyethylene Glycol (PEG)	≤ 2.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.