Description

1-Boc-4-(2-Hydroxycyclopentyl)Piperazine is a high-purity, advanced pharmaceutical intermediate featuring a piperazine ring protected by a tert-butoxycarbonyl (Boc) group and substituted with a hydroxycyclopentyl moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical companies and research institutions engaged in the discovery and development of new therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug discovery programs.
• Protease Inhibitor Synthesis: Serves as a precursor in the development of protease inhibitors for various therapeutic applications.
• Kinase Inhibitor Development: Employed in the construction of heterocyclic scaffolds for kinase inhibitor libraries.
• Chemical Biology Probes: Utilized to create molecular probes for studying biological pathways and target engagement.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical synthesis services.

Basic Information

Product Name	1-Boc-4-(2-Hydroxycyclopentyl)Piperazine
CAS No.	1267023-34-6
Molecular Formula	C14H26N2O3
Molecular Weight	270.37 g/mol
Synonyms	1-Boc-4-(2-Hydroxycyclopentyl)piperazine; tert-Butyl 4-(2-hydroxycyclopentyl)piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(2-hydroxycyclopentyl)piperazine; 4-(2-Hydroxycyclopentyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; N-Boc-4-(2-hydroxycyclopentyl)piperazine; 1,1-Dimethylethyl 4-(2-hydroxycyclopentyl)-1-piperazinecarboxylate; Piperazine, 1-(1,1-dimethylethoxy)carbonyl-4-(2-hydroxycyclopentyl)-
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(2-Hydroxycyclopentyl)Piperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and the absence of critical impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We adhere to cGMP guidelines for the production of pharmaceutical intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture uptake. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.