Description

tert-Butyl 4-(2-Bromopyridin-4-Yl)Piperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a bromopyridine and a Boc-protected piperazine moiety. This compound is a critical building block for medicinal chemists, enabling the efficient synthesis of complex molecules with potential therapeutic activity. It is primarily utilized in the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Kinase Inhibitor Development: Used to construct core scaffolds for potential kinase inhibitors, a major class of oncology and anti-inflammatory therapeutics.
• CNS-Active Compound Synthesis: Serves as a building block for molecules designed to cross the blood-brain barrier for neurological and psychiatric applications.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed in the construction of linkers and ligands for targeted protein degradation technologies.
• Agrochemical Research: Can be utilized in the discovery of new active ingredients for crop protection products.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for custom synthesis projects and scale-up activities.

Basic Information

Product Name	tert-Butyl 4-(2-Bromopyridin-4-Yl)Piperazine-1-Carboxylate
CAS No.	1266118-96-0
Molecular Formula	C14H20BrN3O2
Molecular Weight	342.23 g/mol
Synonyms	1-Boc-4-(2-Bromo-4-pyridyl)piperazine; 4-(2-Bromopyridin-4-yl)-1-(tert-butoxycarbonyl)piperazine; tert-Butyl 4-(2-bromo-4-pyridinyl)-1-piperazinecarboxylate; 1-(tert-Butoxycarbonyl)-4-(2-bromopyridin-4-yl)piperazine; 2-Bromo-4-(1-Boc-piperazin-4-yl)pyridine; 4-(2-Bromopyridin-4-yl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Bromopyridin-4-Yl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.