Description

2-((R)-Pyrrolidin-3-Yloxy)-Pyrazine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other targeted therapies.
• Medicinal Chemistry Research: Used as a versatile building block for constructing compound libraries and exploring structure-activity relationships (SAR) in drug discovery programs.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions due to its chiral pyrrolidine-oxygen scaffold.
• Ligand and Catalyst Development: Serves as a precursor for the development of novel chiral ligands and organocatalysts.
• Reference Standard: Utilized as an analytical standard for quality control and method development in pharmaceutical analysis.
• Preclinical Development: Supports scale-up synthesis for preclinical studies and early-stage clinical trial material (CTM) manufacturing.

Basic Information

Product Name	2-((R)-Pyrrolidin-3-Yloxy)-Pyrazine Hydrochloride
CAS No.	1264035-13-3
Molecular Formula	C8H12ClN3O
Molecular Weight	201.66 g/mol
Synonyms	(R)-2-(Pyrrolidin-3-yloxy)pyrazine hydrochloride; 2-[(3R)-Pyrrolidin-3-yloxy]pyrazine hydrochloride; Pyrazine, 2-[(3R)-3-pyrrolidinyloxy]-, hydrochloride; 1264035-13-3; (R)-3-((Pyrazin-2-yl)oxy)pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our 2-((R)-Pyrrolidin-3-Yloxy)-Pyrazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.