Description

Methyl 4-Bromonicotinate is a high-purity, versatile brominated nicotinate ester building block. This compound is essential for advanced organic synthesis, particularly in the construction of complex heterocyclic systems. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially kinase inhibitors and other biologically active nitrogen-containing heterocycles.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials, liquid crystals, and functional polymers.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Academic & Industrial R&D: A valuable reagent for method development and exploratory chemistry in both university and corporate laboratory settings.

Basic Information

Product Name	Methyl 4-Bromonicotinate
CAS No.	1263378-22-8
Molecular Formula	C7H6BrNO2
Molecular Weight	216.03 g/mol
Synonyms	4-Bromonicotinic Acid Methyl Ester; Methyl 4-Bromopyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 4-bromo-, methyl ester; 4-Bromo-3-pyridinecarboxylic acid methyl ester; 4-Bromonicotinic acid methyl ester; Methyl 4-bromo-3-pyridinecarboxylate; 1263378-22-8
EINECS	Contact for details

Quality Control

Our Methyl 4-Bromonicotinate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.