Description

2-Piperazinemethanol, 1-[(3-Chlorophenyl)Methyl]-, (2R)- is a chiral piperazine derivative of significant interest in advanced pharmaceutical synthesis. This compound serves as a critical chiral building block and intermediate for the development of active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high stereochemical purity. It is essential for research chemists and process development scientists in the pharmaceutical and fine chemical industries seeking to develop novel drug candidates with specific enantiomeric profiles.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel APIs, especially for central nervous system (CNS) and psychiatric disorder treatments.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce enantioselectivity.
• Medicinal Chemistry Research: Serves as a core scaffold for constructing compound libraries in drug discovery programs targeting G-protein coupled receptors (GPCRs).
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable, cost-effective synthetic routes for chiral drug molecules.
• Reference Standard: Used as a high-purity analytical standard for method development and quality control in regulatory submissions.

Basic Information

Product Name	2-Piperazinemethanol, 1-[(3-Chlorophenyl)Methyl]-, (2R)-
CAS No.	1263286-37-8
Molecular Formula	C12H17ClN2O
Molecular Weight	240.73 g/mol
Synonyms	(2R)-1-[(3-Chlorophenyl)methyl]-2-piperazinemethanol; (R)-1-(3-Chlorobenzyl)-2-piperazinemethanol; (R)-1-((3-Chlorophenyl)methyl)piperazin-2-yl)methanol; UNII-8Q7F0S4X0F; 1-[(3-Chlorophenyl)Methyl]-2-piperazinemethanol, (R)-; (R)-1-(3-Chlorobenzyl)piperazine-2-methanol; 1263286-37-8; (R)-1-(3-Chlorobenzyl)-2-(hydroxymethyl)piperazine
EINECS	Contact for details

Quality Control

Our 2-Piperazinemethanol, 1-[(3-Chlorophenyl)Methyl]-, (2R)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.