Description

tert-Butyl 4-Cyano-4-(4-(3-Methylpyrazin-2-Yl)Phenyl)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery. This compound serves as a critical building block for the synthesis of novel therapeutic agents, particularly in the development of kinase inhibitors and other targeted small molecule drugs. It is primarily sought by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in preclinical and process development for oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Synthesis: Core scaffold for constructing potent and selective kinase inhibitors targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to improve drug potency and selectivity.
• Process Chemistry & Scale-Up: Serves as a defined starting material for process route development and GMP manufacturing of clinical trial materials.
• Bioconjugation & Probe Development: The cyano and protected amine groups offer handles for further chemical modification in creating biochemical probes.

Basic Information

Product Name	tert-Butyl 4-Cyano-4-(4-(3-Methylpyrazin-2-Yl)Phenyl)Piperidine-1-Carboxylate
CAS No.	1263284-70-3
Molecular Formula	C22H26N4O2
Molecular Weight	378.47 g/mol
Synonyms	1-Boc-4-Cyano-4-[4-(3-methylpyrazin-2-yl)phenyl]piperidine; 4-Cyano-4-[4-(3-methyl-2-pyrazinyl)phenyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-cyano-4-[4-(3-methylpyrazin-2-yl)phenyl]piperidine; tert-Butyl 4-cyano-4-[4-(3-methylpyrazin-2-yl)phenyl]piperidine-1-carboxylate; BOC-4-Cyano-4-(4-(3-methylpyrazin-2-yl)phenyl)piperidine; CAS 1263284-70-3
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Cyano-4-(4-(3-Methylpyrazin-2-Yl)Phenyl)Piperidine-1-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ISO 9001 quality management standards, and our processes are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.