Description

2,6-Piperazinedione, 4,4′-[(1S)-1-Methyl-1,2-Ethanediyl]Bis-, Hydrochloride (1:1) is a high-purity, stereochemically defined piperazinedione derivative supplied as a hydrochloride salt. This compound is a critical chiral building block and intermediate in advanced pharmaceutical research and development, particularly for the synthesis of complex active pharmaceutical ingredients (APIs). It is essential for medicinal chemists and process development scientists working in oncology, neurology, and other therapeutic areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel therapeutic agents.
• API Development: Used as a building block in the development of complex Active Pharmaceutical Ingredients (APIs), especially those targeting specific biological pathways.
• Medicinal Chemistry Research: Serves as a core structure for structure-activity relationship (SAR) studies and the creation of focused compound libraries.
• Process Chemistry: Employed in route scouting and optimization for scalable GMP manufacturing of drug candidates.
• Bioconjugation & Probe Synthesis: Potential utility in creating chemical probes or conjugates for biochemical and diagnostic applications due to its reactive sites.
• Academic & Institutional Research: Used in universities and research institutes for fundamental studies in organic synthesis and chemical biology.

Basic Information

Product Name	2,6-Piperazinedione, 4,4′-[(1S)-1-Methyl-1,2-Ethanediyl]Bis-, Hydrochloride (1:1)
CAS No.	1263283-43-7
Molecular Formula	C12H20N4O4 • HCl
Molecular Weight	328.77 g/mol (free base: 284.31 g/mol)
Synonyms	(1S)-1,2-Bis(2,6-dioxopiperazin-4-yl)propane hydrochloride; 4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis-2,6-piperazinedione hydrochloride; L-1,2-Bis(2,6-dioxopiperazin-4-yl)propane HCl; (S)-1,2-Bis(2,6-dioxopiperazin-4-yl)propane hydrochloride; 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, hydrochloride, (S)-; UNII-7Q5P6U4I7O (component); Piperazinedione derivative hydrochloride salt; Chiral bis(piperazinedione) hydrochloride
EINECS	Contact for details

Quality Control

Our 2,6-Piperazinedione, 4,4′-[(1S)-1-Methyl-1,2-Ethanediyl]Bis-, Hydrochloride (1:1) is manufactured under strict quality systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, chiral purity, and impurity profiles. Our quality commitment supports development from research to regulatory submission.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.