Description

(3S,4S)-(3-Methyl-Piperidin-4-Yl)-Carbamic Acid tert-Butyl Ester is a high-purity chiral piperidine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a stereochemically defined, protected amine functional group essential for constructing complex molecular architectures. This intermediate is primarily needed by pharmaceutical R&D and process chemistry teams for the development of active pharmaceutical ingredients (APIs), particularly in neurological and therapeutic agent discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Asymmetric Synthesis: Utilized in the construction of complex molecules requiring precise stereochemical control at the 3- and 4-positions of the piperidine ring.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing for APIs.
• Custom Synthesis: A starting material for the preparation of more elaborate, proprietary compounds for specialized research applications.

Basic Information

Product Name	(3S,4S)-(3-Methyl-Piperidin-4-Yl)-Carbamic Acid tert-Butyl Ester
CAS No.	1262787-68-7
Molecular Formula	C12H24N2O2
Molecular Weight	228.33 g/mol
Synonyms	tert-Butyl (3S,4S)-3-methylpiperidin-4-ylcarbamate; (3S,4S)-N-Boc-3-methyl-4-aminopiperidine; Boc-(3S,4S)-3-methyl-4-aminopiperidine; (3S,4S)-1-Boc-3-methylpiperidin-4-amine; tert-Butyl (3S,4S)-3-methyl-4-piperidinylcarbamate; (3S-cis)-3-Methyl-4-piperidinamine, 1-(1,1-dimethylethoxy)carbonyl-; Boc-3-methyl-4-aminopiperidine (3S,4S)-isomer
EINECS	Contact for details

Quality Control

Our (3S,4S)-(3-Methyl-Piperidin-4-Yl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive analytical data, including chiral purity and impurity profiles, to support regulatory filings. Certificates of Analysis (COA) detailing identity, assay, and purity by HPLC are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.