Description

3,3-Difluoro-5-Hydroxymethyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-value, multifunctional piperidine derivative serving as a critical building block in modern synthetic chemistry. This compound matters for its unique structural features, combining a protected carboxylic acid, a hydroxymethyl group, and geminal difluoro substitution, which are essential for modulating the physicochemical and metabolic properties of target molecules. Pharmaceutical and agrochemical researchers need this advanced intermediate for the development of novel active ingredients, particularly in medicinal chemistry for creating protease inhibitors, kinase modulators, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in protease and kinase inhibitor programs.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to introduce fluorinated motifs and polar functional groups, improving potency and pharmacokinetic profiles.
• Agrochemical Research: Intermediate in the development of new herbicides, fungicides, and insecticides where the difluoropiperidine scaffold confers unique biological activity.
• Chemical Biology: Serves as a versatile scaffold for constructing molecular probes and tool compounds to study enzyme function and biological pathways.
• Peptidomimetics: Used to create constrained, non-natural amino acid analogs for peptide-based drug discovery.
• Material Science: Potential monomer or precursor for specialty polymers and advanced materials with specific fluorine-containing properties.

Basic Information

Product Name	3,3-Difluoro-5-Hydroxymethyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1262412-64-5
Molecular Formula	C12H21F2NO3
Molecular Weight	265.30 g/mol
Synonyms	1-Boc-3,3-difluoro-5-(hydroxymethyl)piperidine; tert-Butyl 3,3-difluoro-5-(hydroxymethyl)piperidine-1-carboxylate; 3,3-Difluoro-5-(hydroxymethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-3,3-difluoro-5-(hydroxymethyl)piperidine; 3,3-Difluoro-5-hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester; N-Boc-3,3-difluoro-5-hydroxymethylpiperidine
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-5-Hydroxymethyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.