Description

(3-Fluoro-Piperidin-3-Ylmethyl)-Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a fluorinated piperidine scaffold, a privileged structure in modern drug discovery. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and binding affinity. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly those targeting G-protein-coupled receptors (GPCRs) and enzymes.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of fluorine substitution and the piperidine moiety on pharmacokinetic and pharmacodynamic properties.
• Protease Inhibitor Development: Serves as a precursor in the creation of inhibitors for various proteases, where the fluorinated piperidine can act as a key pharmacophore.
• Chemical Biology Probes: Employed in the design and synthesis of chemical probes for target identification and validation in biological systems.
• Library Synthesis for High-Throughput Screening: Used to generate focused compound libraries for screening against novel biological targets.
• Process Chemistry & Scale-Up: Serves as a critical intermediate in the route development and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(3-Fluoro-Piperidin-3-Ylmethyl)-Carbamic Acid tert-Butyl Ester
CAS No.	1262408-83-2
Molecular Formula	C11H21FN2O2
Molecular Weight	232.30 g/mol
Synonyms	tert-Butyl N-[(3-fluoro-3-piperidinyl)methyl]carbamate; N-Boc-3-fluoro-3-piperidinemethylamine; 1,1-Dimethylethyl N-[(3-fluoro-3-piperidinyl)methyl]carbamate; Boc-3-Fluoro-3-piperidinylmethylamine; (3-Fluoro-3-piperidinylmethyl)carbamic acid tert-butyl ester; 3-Fluoro-3-piperidinemethylamine, N-Boc-protected; tert-Butyl (3-fluoro-3-piperidinylmethyl)carbamate
EINECS	Contact for details

Quality Control

Our production of (3-Fluoro-Piperidin-3-Ylmethyl)-Carbamic Acid tert-Butyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. All materials are characterized by advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.