Description

tert-Butyl 1-(Methylsulfonyl)Piperidin-3-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine carbamate structure with a methylsulfonyl protecting group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of targeted therapeutics, including kinase inhibitors and other small molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) research.
• Medicinal Chemistry Building Block: Used for structure-activity relationship (SAR) studies and lead optimization due to its modifiable piperidine and carbamate functional groups.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) and methylsulfonyl (Ms) groups offer orthogonal protection schemes in complex organic syntheses.
• Process Chemistry Development: Serves as a standardized intermediate for scaling up API manufacturing processes under current Good Manufacturing Practice (cGMP) guidelines.
• Bioconjugation & Probe Synthesis: Potential use in creating chemical probes or conjugates for biochemical and pharmacological studies.

Basic Information

Product Name	tert-Butyl 1-(Methylsulfonyl)Piperidin-3-Ylcarbamate
CAS No.	1262310-00-8
Molecular Formula	C12H24N2O4S
Molecular Weight	292.40 g/mol
Synonyms	3-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-(methylsulfonyl)piperidine; 1-(Methylsulfonyl)piperidin-3-amine, N-Boc derivative; tert-Butyl N-[1-(methylsulfonyl)piperidin-3-yl]carbamate; 3-(Boc-amino)-1-methanesulfonylpiperidine; BOC-3-Amino-1-methanesulfonylpiperidine; 1-Methanesulfonyl-3-piperidinamine, N-BOC protected; tert-Butyl (1-(methylsulfonyl)piperidin-3-yl)carbamate
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 1-(Methylsulfonyl)Piperidin-3-Ylcarbamate is manufactured and tested to meet stringent quality standards suitable for research and development applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing full traceability and detailed analytical results from techniques including HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.