Description

1-(2-Bromo-5-Chlorophenyl)-4-Methylpiperazine is a high-purity, advanced pharmaceutical intermediate characterized by its halogenated aromatic and piperazine structure. This compound is of significant commercial importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted drug discovery. It is primarily required by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially those targeting neurological and psychiatric disorders.
• Chemical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization processes.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core scaffold for constructing complex molecules with potential antipsychotic, antidepressant, or anxiolytic activity.
• Contract Manufacturing: Supplied to CDMOs for scale-up production under current Good Manufacturing Practice (cGMP) conditions for clinical trial material.
• Life Science Reagents: Utilized in biochemical research as a tool compound for studying receptor-ligand interactions and signal transduction pathways.

Basic Information

Product Name	1-(2-Bromo-5-Chlorophenyl)-4-Methylpiperazine
CAS No.	1261940-25-3
Molecular Formula	C11H14BrClN2
Molecular Weight	289.60 g/mol
Synonyms	4-Methyl-1-(2-bromo-5-chlorophenyl)piperazine; 2-Bromo-5-chloro-N-methyl-N-(piperazin-1-yl)aniline; 1-(2-Bromo-5-chlorophenyl)-4-methylpiperazine; 4-Methyl-1-(2-bromo-5-chlorophenyl)piperazine; 2-Bromo-5-chloro-1-(4-methylpiperazin-1-yl)benzene; (2-Bromo-5-chlorophenyl)(4-methylpiperazin-1-yl)methanone (tautomer consideration); 1261940-25-3
EINECS	Contact for details

Quality Control

Our 1-(2-Bromo-5-Chlorophenyl)-4-Methylpiperazine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.