Description

4-(3-Chloro-5-Fluorophenyl)-2-Hydroxypyridine is a high-purity, advanced pharmaceutical intermediate with a distinct halogenated biphenyl-pyridine structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is essential for research and development chemists, process scale-up teams, and manufacturers in the pharmaceutical, agrochemical, and specialty fine chemical industries seeking reliable, high-quality intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially for central nervous system (CNS) and oncology targets.
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging its halogenated aromatic system for bioactivity.
• Ligand Synthesis: Serves as a starting material for creating complex ligands in catalysis and material science.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Organic Electronic Materials: Investigated as a component in the development of organic semiconductors and light-emitting materials.

Basic Information

Product Name	4-(3-Chloro-5-Fluorophenyl)-2-Hydroxypyridine
CAS No.	1261938-64-0
Molecular Formula	C11H7ClFNO
Molecular Weight	223.63 g/mol
Synonyms	2-Hydroxy-4-(3-chloro-5-fluorophenyl)pyridine; 4-(3-Chloro-5-fluorophenyl)pyridin-2-ol; 2-Pyridinol, 4-(3-chloro-5-fluorophenyl)-; 4-(3-Chloro-5-fluorophenyl)-2(1H)-pyridinone (Tautomeric form); 3-Chloro-5-fluoro-4-(2-pyridyl)phenol
EINECS	Contact for details

Quality Control

Our production of 4-(3-Chloro-5-Fluorophenyl)-2-Hydroxypyridine adheres to stringent quality management protocols. Every batch is subjected to comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for each lot. Our quality system is designed to support cGMP and ISO standards for pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.