Description

5-Chloro-3-Fluoropyridine-2-Sulfonyl Chloride is a high-value, multi-functional chemical intermediate characterized by its reactive sulfonyl chloride and halogenated pyridine core. This compound matters for its critical role in constructing complex molecular architectures, particularly in the synthesis of advanced agrochemicals and pharmaceuticals. It is primarily needed by R&D chemists and process development scientists in the fine chemical, agrochemical, and pharmaceutical industries seeking to introduce sulfonamide or sulfonate functionalities into target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs), including kinase inhibitors and antimicrobial agents.
• Agrochemical Synthesis: Used in the production of modern herbicides and fungicides, where the sulfonyl chloride group enables the creation of potent sulfonylurea or sulfonamide derivatives.
• Material Science Research: Serves as a precursor for functionalized polymers or ligands in catalyst design, leveraging its halogen and sulfonyl chloride handles for further modification.
• Chemical Biology Probes: Utilized in developing activity-based probes or covalent inhibitors for target identification and validation studies in drug discovery.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring precise introduction of a halogenated pyridine-sulfonyl moiety.

Basic Information

Product Name	5-Chloro-3-Fluoropyridine-2-Sulfonyl Chloride
CAS No.	1261737-23-8
Molecular Formula	C5H2Cl2FNO2S
Molecular Weight	249.04 g/mol
Synonyms	2-Chlorosulfonyl-5-chloro-3-fluoropyridine; 3-Fluoro-5-chloropyridine-2-sulfonyl chloride; 5-Chloro-3-fluoro-2-pyridinesulfonyl chloride; 2-Pyridinesulfonyl chloride, 5-chloro-3-fluoro-; 1261737-23-8
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-3-Fluoropyridine-2-Sulfonyl Chloride is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, GC, and NMR, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability and meet your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.