Description

Methyl 3-Fluoropyrazine-2-Carboxylate CAS NO 1261487-49-3 is a high-value fluorinated heterocyclic building block, a methyl ester derivative of a fluoropyrazinecarboxylic acid. This compound is essential for introducing the metabolically stable fluorine atom and the versatile pyrazine core into complex molecular architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluoropyrazine moiety.
• Material Science Precursor: Serves as a building block for functionalized ligands and monomers used in advanced polymers and organic electronic materials.
• Chemical Biology Probe Development: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of molecular probes.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	Methyl 3-Fluoropyrazine-2-Carboxylate
CAS No.	1261487-49-3
Molecular Formula	C6H5FN2O2
Molecular Weight	156.11 g/mol
Synonyms	3-Fluoropyrazine-2-carboxylic acid methyl ester; Methyl 3-fluoropyrazine-2-carboxylate; 2-Pyrazinecarboxylic acid, 3-fluoro-, methyl ester; Methyl 3-fluoro-2-pyrazinecarboxylate; 3-Fluoro-2-pyrazinecarboxylic acid methyl ester; Methyl 3-fluoropyrazinecarboxylate; 1261487-49-3
EINECS	Contact for details

Quality Control

Our Methyl 3-Fluoropyrazine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.