Description

4-Chloro-3-Methoxypyridin-2-Amine is a high-purity, functionalized pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, enabling precise molecular modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials and functional dyes due to its electron-donating methoxy and electron-withdrawing chloro groups.
• Chemical Biology Probes: Utilized to build molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines.

Basic Information

Item	Details
Product Name	4-Chloro-3-Methoxypyridin-2-Amine
CAS No.	1261452-97-4
Molecular Formula	C6H7ClN2O
Molecular Weight	158.58 g/mol
Synonyms	2-Amino-4-chloro-3-methoxypyridine; 4-Chloro-3-methoxy-2-pyridinamine; 3-Methoxy-4-chloropyridin-2-amine; 2-Pyridinamine, 4-chloro-3-methoxy-; 4-Chloro-3-methoxypyridin-2-ylamine; 4-Chloro-3-methoxy-2-aminopyridine
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-3-Methoxypyridin-2-Amine is produced under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS are available upon request. We support development with research-grade to cGMP-compliant material, as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.