Description

5-Chloro-3-Iodo-2-Methoxypyridine is a halogenated pyridine derivative of significant interest in advanced organic synthesis. This compound serves as a versatile and valuable building block for the construction of complex molecular architectures, particularly in pharmaceutical and agrochemical research. Its unique substitution pattern makes it an essential intermediate for medicinal chemists and process development scientists seeking to introduce specific halogenated motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of organic electronic materials and liquid crystals due to its electron-deficient pyridine core.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes and tags for studying biological processes.
• Custom Synthesis and Contract Manufacturing: A critical raw material for custom synthesis organizations (CSOs) and CDMOs serving the global life sciences industry.

Basic Information

Product Name	5-Chloro-3-Iodo-2-Methoxypyridine
CAS No.	1261365-72-3
Molecular Formula	C6H5ClINO
Molecular Weight	269.47 g/mol
Synonyms	2-Methoxy-5-chloro-3-iodopyridine; 3-Iodo-5-chloro-2-methoxypyridine; 5-Chloro-3-iodo-2-pyridinol methyl ether; 2-Pyridinol, 5-chloro-3-iodo-, methyl ether
EINECS	Contact for details

Quality Control

Our 5-Chloro-3-Iodo-2-Methoxypyridine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade starting materials and aligns with ICH guidelines for impurity profiling.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.