Description

5-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine-4-Carbonitrile is a high-value, multi-functional heterocyclic building block characterized by its fused pyrrolopyridine core, nitrile group, and trifluoromethyl substituent. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, receptor antagonists, and other small-molecule therapeutics targeting oncology, CNS disorders, and inflammatory diseases.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl and nitrile groups.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient aromatic system.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes and labeled compounds for biochemical and pharmacological studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	5-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine-4-Carbonitrile
CAS No.	1261365-58-5
Molecular Formula	C9H4F3N3
Molecular Weight	211.15 g/mol
Synonyms	4-Cyano-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile, 5-(trifluoromethyl)-; 5-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile; 5-(Trifluoromethyl)-4-cyanopyrrolo[2,3-b]pyridine; Pyrrolo[2,3-b]pyridine-4-carbonitrile, 5-(trifluoromethyl)-; 1261365-58-5; 5-Trifluoromethyl-pyrrolo[2,3-b]pyridine-4-carbonitrile
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine-4-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP, ICH Q7 guidelines, and relevant customer-specific requirements for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.