Description

4-(2-Chloro-6-Methyl-Pyrimidin-4-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its piperazine and substituted pyrimidine structure. This compound is critical for research and development in medicinal chemistry, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those targeting kinase inhibition.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• API Synthesis: Serves as a precursor in multi-step synthetic routes for the production of potential active pharmaceutical ingredients.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects requiring specialized heterocyclic chemistry.

Basic Information

Product Name	4-(2-Chloro-6-Methyl-Pyrimidin-4-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1261234-68-7
Molecular Formula	C14H21ClN4O2
Molecular Weight	312.80 g/mol
Synonyms	tert-Butyl 4-(2-chloro-6-methylpyrimidin-4-yl)piperazine-1-carboxylate; 1-Boc-4-(2-chloro-6-methyl-4-pyrimidinyl)piperazine; 4-(2-Chloro-6-methylpyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(2-chloro-6-methyl-4-pyrimidinyl)piperazine; BOC-Piperazine-Pyrimidine Intermediate; CAS 1261234-68-7
EINECS	Contact for details

Quality Control

Our production of 4-(2-Chloro-6-Methyl-Pyrimidin-4-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic (HPLC, GC) and spectroscopic (NMR, IR, MS) techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.