Description

3-((2R)Pyrrolidin-2-Yl)-2-Chloro-5-Fluoropyridine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound is critical for the research and development of novel therapeutic agents, particularly in the field of central nervous system (CNS) and oncology targets. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers requiring a reliable supply of complex, chiral building blocks for drug synthesis.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• CNS Drug Development: Serves as a precursor for compounds targeting neurological disorders, leveraging the pyrrolidine scaffold's bioactivity.
• Oncology Research: Employed in the synthesis of potential kinase inhibitors or other targeted cancer therapies.
• Process Chemistry & Scale-Up: Supplied for route scouting and process optimization from laboratory to pilot plant scale.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	3-((2R)Pyrrolidin-2-Yl)-2-Chloro-5-Fluoropyridine Dihydrochloride
CAS No.	1260847-45-7
Molecular Formula	C9H12Cl3FN2
Molecular Weight	281.56 g/mol
Synonyms	(R)-2-(2-Chloro-5-fluoropyridin-3-yl)pyrrolidine dihydrochloride; 2-Chloro-5-fluoro-3-[(2R)-2-pyrrolidinyl]pyridine dihydrochloride; 3-[(2R)-Pyrrolidin-2-yl]-2-chloro-5-fluoropyridine hydrochloride (1:2); 1260847-45-7; (R)-3-(2-Chloro-5-fluoropyridin-3-yl)pyrrolidine dihydrochloride
EINECS	Contact for details

Quality Control

Our 3-((2R)Pyrrolidin-2-Yl)-2-Chloro-5-Fluoropyridine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under dry conditions to prevent degradation. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.