Description

2-Bromo-3-Methyl-5H-Pyrrolo[2,3-B]Pyrazine is a high-purity, advanced pharmaceutical intermediate belonging to the fused heterocyclic pyrazine class. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in oncology and antiviral therapeutic areas.
• Kinase Inhibitor Synthesis: Serves as a core scaffold for constructing potent and selective kinase inhibitors due to its privileged pyrrolopyrazine structure.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Bioconjugation & Probe Development: The bromo substituent offers a handle for further functionalization via cross-coupling reactions, useful for creating biochemical probes.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex molecules for clinical trials.
• Academic Research: Employed in university and institutional labs for fundamental studies in heterocyclic chemistry and new synthetic methodology development.

Basic Information

Product Name	2-Bromo-3-Methyl-5H-Pyrrolo[2,3-B]Pyrazine
CAS No.	1260812-97-2
Molecular Formula	C7H6BrN3
Molecular Weight	212.05 g/mol
Synonyms	2-Bromo-3-methyl-5H-pyrrolo[2,3-b]pyrazine; 3-Methyl-2-bromo-5H-pyrrolo[2,3-b]pyrazine; 5H-Pyrrolo[2,3-b]pyrazine, 2-bromo-3-methyl-; 2-Bromo-3-methyl-5H-pyrrolo[2,3-b]pyrazin; Pyrrolo[2,3-b]pyrazine, 2-bromo-3-methyl-5H-
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Methyl-5H-Pyrrolo[2,3-B]Pyrazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.