Description

(R)-1-Boc-4-Cbz-2-Isopropyl-Piperazine CAS NO 1260617-38-6 is a high-purity, chiral piperazine derivative that serves as a critical building block in advanced organic synthesis. This compound is essential for the development of novel pharmaceutical candidates, particularly in the creation of complex molecules with specific stereochemical requirements. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and antiviral therapies.
• Peptidomimetic Synthesis: Used to introduce the (R)-2-isopropylpiperazine moiety into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Chemical Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring high stereochemical purity.
• Academic Research: A valuable reagent for universities and research institutes studying heterocyclic chemistry, stereoselective synthesis, and structure-activity relationships (SAR).

Basic Information

Product Name	(R)-1-Boc-4-Cbz-2-Isopropyl-Piperazine
CAS No.	1260617-38-6
Molecular Formula	C20H30N2O4
Molecular Weight	362.47 g/mol
Synonyms	1-Boc-4-Cbz-(2R)-isopropylpiperazine; (R)-1-(tert-Butoxycarbonyl)-4-(benzyloxycarbonyl)-2-(propan-2-yl)piperazine; tert-Butyl (R)-4-[(benzyloxy)carbonyl]-2-(1-methylethyl)-1-piperazinecarboxylate; (R)-2-Isopropyl-1,4-bis(oxycarbonyl)piperazine (Boc/Cbz protected); (R)-N-Boc-N'-Cbz-2-isopropylpiperazine; BOC-CBZ-(R)-2-Isopropylpiperazine; (R)-1,4-Di-Boc/Cbz-2-isopropylpiperazine (common abbreviation)
EINECS	Contact for details

Quality Control

Every batch of (R)-1-Boc-4-Cbz-2-Isopropyl-Piperazine is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including chiral purity verification, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.