Description

(3Ar,6Ar)-tert-Butyl Hexahydropyrrolo[3,2-B]Pyrrole-1(2H)-Carboxylate CAS NO 1260590-44-0 is a high-purity, advanced pharmaceutical intermediate belonging to the class of bicyclic pyrrolidine derivatives. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex molecular architectures with defined stereochemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Asymmetric Synthesis: Serves as a versatile scaffold for constructing enantiomerically pure compounds due to its rigid, defined stereochemistry.
• Protease Inhibitor Development: Potential application as a core structure in the design of inhibitors for various enzymatic targets.
• Chemical Biology: Can be utilized as a molecular probe or tagged ligand for studying biological pathways and target engagement.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	(3Ar,6Ar)-tert-Butyl Hexahydropyrrolo[3,2-B]Pyrrole-1(2H)-Carboxylate
CAS No.	1260590-44-0
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	tert-Butyl (3aR,6aR)-hexahydropyrrolo[3,2-b]pyrrole-1(2H)-carboxylate; (3aR,6aR)-1-Boc-3,6-dihydro-2H-pyrrolo[3,2-b]pyrrole; (3aR,6aR)-1-N-Boc-hexahydropyrrolo[3,2-b]pyrrole; 1-Boc-(3aR,6aR)-hexahydropyrrolo[3,2-b]pyrrole; (3aR,6aR)-Hexahydro-2H-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester; Bicyclic pyrrolidine Boc-protected amine; (3aR,6aR)-1-(tert-Butoxycarbonyl)octahydropyrrolo[3,2-b]pyrrole
EINECS	Contact for details

Quality Control

Our (3Ar,6Ar)-tert-Butyl Hexahydropyrrolo[3,2-B]Pyrrole-1(2H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for advanced research and pre-clinical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development projects requiring compliance with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.