Description

n-Methyl-n-(T-Boc)-Peg4-Acid CAS NO 1260431-01-3 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a Boc-protected amine and a carboxylic acid terminus. This compound is essential for creating stable, water-soluble conjugates in bioconjugation and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the fields of proteomics, antibody-drug conjugate (ADC) development, and peptide synthesis to introduce controlled spacing and solubility.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key spacer to connect cytotoxic payloads to monoclonal antibodies, enhancing solubility and pharmacokinetics.
• Peptide and Protein Modification: Used for site-specific PEGylation to improve stability, reduce immunogenicity, and prolong circulation half-life of therapeutic biomolecules.
• Bioconjugation Reagent: Facilitates the coupling of various molecules (e.g., dyes, drugs, targeting ligands) to biomolecules via its amine-reactive and carboxyl-reactive ends.
• Crosslinking Agent: Employed in the synthesis of hydrogels, polymer networks, and surface functionalization for diagnostic assays and biomaterials.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a building block for introducing PEG spacers into synthetic peptide chains.
• Prodrug Synthesis: Utilized to create cleavable linkers in prodrug designs for controlled drug release.

Basic Information

Product Name	n-Methyl-n-(T-Boc)-Peg4-Acid
CAS No.	1260431-01-3
Molecular Formula	C22H43NO10
Molecular Weight	481.58 g/mol
Synonyms	Boc-NH-PEG4-CH2CH2COOH; 2-[2-[2-[2-[2-(tert-Butoxycarbonyl(methyl)amino)ethoxy]ethoxy]ethoxy]ethoxy]acetic Acid; Boc-N-methyl-PEG4-acid; (Boc-N-methyl-amino)-PEG4-acid; tert-Butyl N-methyl-N-[2-[2-[2-[2-(carboxymethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate; N-Boc-N-methyl-PEG4-acid; N-(tert-Butoxycarbonyl)-N-methyl-3,6,9,12-tetraoxapentadecan-15-oic Acid; Boc-N-Me-PEG4-COOH
EINECS	Contact for details

Quality Control

Our n-Methyl-n-(T-Boc)-Peg4-Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency for critical research and cGMP-grade applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.