Description

5-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine-4-Carboxylic Acid is a high-value heterocyclic building block featuring a fused pyrrolopyridine core and a carboxylic acid functional group. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, receptor antagonists, and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyrrolopyridine scaffold.
• Material Science Precursor: Serves as a building block for organic electronic materials and metal-organic frameworks (MOFs) due to its rigid, planar structure and functional handles.
• Chemical Biology Probe Development: Employed in creating tool compounds and fluorescent tags for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific target molecules at various scales.

Basic Information

Product Name	5-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine-4-Carboxylic Acid
CAS No.	1260384-46-0
Molecular Formula	C9H5F3N2O2
Molecular Weight	230.15 g/mol
Synonyms	4-Pyridinecarboxylic acid, 5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-; 5-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid; 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 5-(trifluoromethyl)-; 5-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid; 1260384-46-0; 5-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4-carboxylate
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.