Description

4-(2-Hydroxy-Ethoxymethyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected piperidine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its functionalized structure, which provides a versatile scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking reliable, high-quality intermediates for API synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting the central nervous system and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the piperidine moiety with a protected amine and a functionalized side chain.
• Process Chemistry Development: Serves as a standardized intermediate for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions.
• Agrochemical Synthesis: Employed in the research and production of novel crop protection agents and pesticides.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring a specific, protected heterocyclic framework.
• Chemical Biology & Proteomics: Can be utilized as a linker or spacer molecule in the development of biochemical probes and tools.

Basic Information

Product Name	4-(2-Hydroxy-Ethoxymethyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1260099-72-6
Molecular Formula	C14H27NO4
Molecular Weight	273.37 g/mol
Synonyms	1-Boc-4-(2-hydroxyethoxymethyl)piperidine; tert-Butyl 4-[(2-hydroxyethoxy)methyl]piperidine-1-carboxylate; 4-(2-Hydroxyethoxy)methyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1-N-Boc-4-(2-hydroxyethoxymethyl)piperidine; 4-(2-Hydroxyethoxymethyl)piperidine-1-carboxylic acid tert-butyl ester; Boc-4-(2-hydroxyethoxymethyl)piperidine; 1-(tert-Butoxycarbonyl)-4-(2-hydroxyethoxymethyl)piperidine
EINECS	Contact for details

Quality Control

Our production of 4-(2-Hydroxy-Ethoxymethyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is manufactured and tested in facilities that operate under ISO 9001 quality systems, with options available for synthesis under cGMP guidelines for advanced pharmaceutical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.