Description

T-Boc-n-Amido-Peg1-Acid CAS NO 1260092-44-1 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a tert-butyloxycarbonyl (BOC) protected amine and a carboxylic acid terminus. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the controlled synthesis of peptide and protein conjugates, drug-linker complexes, and advanced biomaterials. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for creating novel therapeutics and diagnostic agents.

Application

• Pharmaceutical Linker Synthesis: A key intermediate for constructing cleavable or non-cleavable linkers in Antibody-Drug Conjugates (ADCs) and other targeted drug delivery systems.
• Peptide Modification & PEGylation: Used to introduce a protected amine handle and a hydrophilic PEG spacer for enhancing the solubility, stability, and pharmacokinetic properties of therapeutic peptides.
• Bioconjugation Reagent: Facilitates the site-specific coupling of biomolecules (e.g., proteins, antibodies) to drugs, dyes, or solid surfaces via its orthogonal reactive groups.
• Polymer Chemistry: Serves as a functional monomer or chain extender in the synthesis of functionalized, biocompatible polymers for biomedical applications.
• Proteomics Research: Employed in the development of chemical probes and affinity tags for studying protein function and interactions.
• Material Science: Used to create functionalized surfaces and hydrogels with specific biological activity for tissue engineering and biosensor development.

Basic Information

Product Name	T-Boc-n-Amido-Peg1-Acid
CAS No.	1260092-44-1
Molecular Formula	C12H23NO5
Molecular Weight	261.32 g/mol
Synonyms	2-[2-(tert-Butoxycarbonylamino)ethoxy]acetic Acid; 2-[2-[(tert-Butoxycarbonyl)amino]ethoxy]acetic Acid; Boc-NH-PEG1-CH2COOH; Boc-Amino-PEG1-Acid; tert-Butyl N-(2-carboxymethoxyethyl)carbamate; BOC-N-Amido-PEG1-Acid; T-Boc-Aminoethoxyacetic Acid; (2-{[(tert-Butoxy)carbonyl]amino}ethoxy)acetic Acid
EINECS	Contact for details

Quality Control

Our T-Boc-n-Amido-Peg1-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.